1995), while apparently binding to different consensus DNA sequences ( Woods and Whitelaw 2002). 1997), both proteins form heterodimers with ARNT, ARNT2, ARNT3 (BMAL1/MOP3) ( Yang et al. While it appears that SIM1 and AHR do not interact directly ( Probst et al. The effects of TCDD on the regulation of food intake are attributed to perturbations occurring within the hypothalamus, the primary region of SIM1 activity. Rats exhibit differential susceptibility to TCDD-induced wasting syndrome, and TCDD-resistant strains have an allelic mutation that leads to reduced expression of the wild-type AHR allele ( Moffat et al. SIM1 is a bHLH/PAS protein family member required for the development of neuronal cells of the paraventricular nucleus (PVN), a region of the hypothalamus that is critical for energy balance and blood pressure regulation ( Michaud et al. Puga, in Comprehensive Toxicology, 2010 2.07.2.2.4 SIM1
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